Rochelle D. Schwartz-Bloom
Professor in Pharmacology & Cancer Biology
Dr. Schwartz-Bloom is a co-principal investigator for the National Science Foundation Phase II Noyce Fellowship program.
The Schwartz-Bloom laboratory has completed 18 years of research investigating novel pharmacologic approaches to prevent neuronal death caused by cerebral ischemia associated with cardiac arrest and stroke. The group studied how GABA neurotransmission dysfunction contributes to the death of hippocampal neurons after ischemia in vivo or in vitro. Dr. Schwartz-Bloom’s research program continues now exclusively in science education, which she started in 1996. With funds provided by the Duke Provost in 2007, Dr. Schwartz-Bloom established Duke Center for Science Education, an umbrella for all Duke-related activities in science education. She coordinates Duke faculty and student interests in curriculum development, research, and outreach activities in science education for the K-16 grades. Dr. Schwartz-Bloom also directs RISE (Raising Interest in Science Education, http://sites.duke.edu/rise), an office within the Department of Pharmacology and Cancer Biology, where she develops and provides novel science education curricular materials in the area of pharmacology to the K-12 and college community. One of the major programs that she developed is the Pharmacology Education Partnership (http://sites.duke.edu/thepepproject), a series of pharmacology- and drug abuse-related science education modules for high school biology and chemistry students. Testing of over 15,000 high school students has revealed that student performance in biology and chemistry improves when they use the pharmacology curriculum developed by her team. Dr. Schwartz-Bloom provides several opportunities for Duke Pharmacology graduate students and post-doctoral fellows to obtain experience in teaching.
- Ph.D., Georgetown University 1983
Inglefield, JR, and Schwartz-Bloom, RD. "Fluorescence imaging of changes in intracellular chloride in living brain slices." Methods 18.2 (June 1999): 197-203. Full Text
Chistina Grobin, A, Inglefield, JR, Schwartz-Bloom, RD, Devaud, LL, and Morrow, AL. "Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties." Brain Res 827.1-2 (May 8, 1999): 1-11.
Inglefield, JR, and Schwartz-Bloom, RD. "Using confocal microscopy and the fluorescent indicator, 6-methoxy-N-ethylquinolinium iodide, to measure changes in intracellular chloride." Methods Enzymol 307 (1999): 469-481.
Sah, R, and Schwartz-Bloom, RD. "Imaging area CA1 hippocampal neurons in the brain slice after exposure to hydrogen peroxide: Effects on intracellular chloride." JOURNAL OF NEUROCHEMISTRY 72 (1999): S34-S34.
Inglefield, JR, and Schwartz-Bloom, RD. "Activation of excitatory amino acid receptors in the rat hippocampal slice increases intracellular Cl- and cell volume." J Neurochem 71.4 (October 1998): 1396-1404.
Schwartz-Bloom, RD. "Long-term neuroprotection of benzodiazepine: Full versus partial agonists after transient cerebral ischemia in the gerbil (vol 18, pg 548, 1998)." JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 18.7 (July 1998): 817-817.
Inglefield, JR, and Schwartz-Bloom, RD. "Optical imaging of hippocampal neurons with a chloride-sensitive dye: early effects of in vitro ischemia." J Neurochem 70.6 (June 1998): 2500-2509.
Schwartz-Bloom, RD, McDonough, KJ, Chase, PJ, Chadwick, LE, Inglefield, JR, and Levin, ED. "Long-term neuroprotection by benzodiazepine full versus partial agonists after transient cerebral ischemia in the gerbil [corrected]." J Cereb Blood Flow Metab 18.5 (May 1998): 548-558. Full Text
Gabriel, EM, Inglefield, JR, Chadwick, LE, and Schwartz-Bloom, RD. "Ischemic injury and extracellular amino acid accumulation in hippocampal area CA1 are not dependent upon an intact septo-hippocampal pathway." Brain Res 785.2 (March 2, 1998): 279-286.