Rochelle D. Schwartz-Bloom
Professor Emeritus of Pharmacology & Cancer Biology
Dr. Schwartz-Bloom is a co-principal investigator for the National Science Foundation Phase II Noyce Fellowship program.
The Schwartz-Bloom laboratory has completed 18 years of research investigating novel pharmacologic approaches to prevent neuronal death caused by cerebral ischemia associated with cardiac arrest and stroke. The group studied how GABA neurotransmission dysfunction contributes to the death of hippocampal neurons after ischemia in vivo or in vitro. Dr. Schwartz-Bloom’s research program continued in the area of science education, which she started in 1996. Her science education research has included the development of novel science education curricular materials in the area of pharmacology to the K-12 and college community. One of the major programs that she developed is the Pharmacology Education Partnership (http://sites.duke.edu/thepepproject), a series of pharmacology- and drug abuse-related science education modules for high school biology and chemistry students. Testing of over 15,000 high school students has revealed that student performance in biology and chemistry improves when they use the pharmacology curriculum developed by her team. All of Dr. Schwartz-Bloom's science education research activities are found on her website for Raising Interest in Science Education, or RISE at http://sites.duke.edu/rise.
With funds provided by the Duke Provost in 2007, Dr. Schwartz-Bloom also established the Duke Center for Science Education, an umbrella for all Duke-related activities in science education. The Center helps to coordinate Duke faculty and student interests in curriculum development, research, and outreach activities in science education for the K-16 grades.
- Ph.D., Georgetown University 1983
Inglefield, J. R., and R. D. Schwartz-Bloom. “Fluorescence imaging of changes in intracellular chloride in living brain slices.” Methods, vol. 18, no. 2, June 1999, pp. 197–203. Pubmed, doi:10.1006/meth.1999.0772. Full Text
Chistina Grobin, A., et al. “Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties.” Brain Res, vol. 827, no. 1–2, May 1999, pp. 1–11. Pubmed, doi:10.1016/s0006-8993(99)01223-8. Full Text
Inglefield, J. R., and R. D. Schwartz-Bloom. “Using confocal microscopy and the fluorescent indicator, 6-methoxy-N-ethylquinolinium iodide, to measure changes in intracellular chloride.” Methods Enzymol, vol. 307, 1999, pp. 469–81. Pubmed, doi:10.1016/s0076-6879(99)07028-7. Full Text
Sah, R., and R. D. Schwartz-Bloom. “Imaging area CA1 hippocampal neurons in the brain slice after exposure to hydrogen peroxide: Effects on intracellular chloride.” Journal of Neurochemistry, vol. 72, LIPPINCOTT WILLIAMS & WILKINS, Jan. 1999, pp. S34–S34.
Bloom, P. N., et al. “A field experiment using the foot-in-the-door technique to recruit teen smokers to smoking cessation programs.” Social Marketing Quarterly, vol. 4, no. 4, Dec. 1998, pp. 61–63. Scopus, doi:10.1080/15245004.1998.9961020. Full Text
Inglefield, J. R., and R. D. Schwartz-Bloom. “Activation of excitatory amino acid receptors in the rat hippocampal slice increases intracellular Cl- and cell volume.” J Neurochem, vol. 71, no. 4, Oct. 1998, pp. 1396–404. Pubmed, doi:10.1046/j.1471-4159.1998.71041396.x. Full Text
Schwartz-Bloom, R. D. “Long-term neuroprotection of benzodiazepine: Full versus partial agonists after transient cerebral ischemia in the gerbil (vol 18, pg 548, 1998).” Journal of Cerebral Blood Flow and Metabolism, vol. 18, no. 7, LIPPINCOTT WILLIAMS & WILKINS, July 1998, pp. 817–817.
Inglefield, J. R., and R. D. Schwartz-Bloom. “Optical imaging of hippocampal neurons with a chloride-sensitive dye: early effects of in vitro ischemia.” J Neurochem, vol. 70, no. 6, June 1998, pp. 2500–09. Pubmed, doi:10.1046/j.1471-4159.1998.70062500.x. Full Text
Schwartz-Bloom, R. D., et al. “Long-term neuroprotection by benzodiazepine full versus partial agonists after transient cerebral ischemia in the gerbil [corrected].” J Cereb Blood Flow Metab, vol. 18, no. 5, May 1998, pp. 548–58. Pubmed, doi:10.1097/00004647-199805000-00010. Full Text
Gabriel, E. M., et al. “Ischemic injury and extracellular amino acid accumulation in hippocampal area CA1 are not dependent upon an intact septo-hippocampal pathway.” Brain Res, vol. 785, no. 2, Mar. 1998, pp. 279–86. Pubmed, doi:10.1016/s0006-8993(97)01415-7. Full Text