Rochelle D. Schwartz-Bloom
Professor Emeritus of Pharmacology & Cancer Biology
Dr. Schwartz-Bloom is a co-principal investigator for the National Science Foundation Phase II Noyce Fellowship program.
The Schwartz-Bloom laboratory has completed 18 years of research investigating novel pharmacologic approaches to prevent neuronal death caused by cerebral ischemia associated with cardiac arrest and stroke. The group studied how GABA neurotransmission dysfunction contributes to the death of hippocampal neurons after ischemia in vivo or in vitro. Dr. Schwartz-Bloom’s research program continued in the area of science education, which she started in 1996. Her science education research has included the development of novel science education curricular materials in the area of pharmacology to the K-12 and college community. One of the major programs that she developed is the Pharmacology Education Partnership (http://sites.duke.edu/thepepproject), a series of pharmacology- and drug abuse-related science education modules for high school biology and chemistry students. Testing of over 15,000 high school students has revealed that student performance in biology and chemistry improves when they use the pharmacology curriculum developed by her team. All of Dr. Schwartz-Bloom's science education research activities are found on her website for Raising Interest in Science Education, or RISE at http://sites.duke.edu/rise.
With funds provided by the Duke Provost in 2007, Dr. Schwartz-Bloom also established the Duke Center for Science Education, an umbrella for all Duke-related activities in science education. The Center helps to coordinate Duke faculty and student interests in curriculum development, research, and outreach activities in science education for the K-16 grades.
- Ph.D., Georgetown University 1983
Luu, M. D., et al. “Characterization of GABAA receptor-mediated 36chloride uptake in rat brain synaptoneurosomes.” Life Sci, vol. 41, no. 10, Sept. 1987, pp. 1277–87. Pubmed, doi:10.1016/0024-3205(87)90207-4. Full Text
Schwartz, R. D., et al. “Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain.” Brain Res, vol. 411, no. 1, May 1987, pp. 151–55. Pubmed, doi:10.1016/0006-8993(87)90692-5. Full Text
Caspers, M. L., et al. “Autoradiographic visualization and characterization of [3H]ouabain binding to the Na+,K+-ATPase of rat brain and pineal.” Brain Res, vol. 409, no. 2, Apr. 1987, pp. 335–42. Pubmed, doi:10.1016/0006-8993(87)90719-0. Full Text
Majewska, M. D., and R. D. Schwartz. “Pregnenolone-sulfate: an endogenous antagonist of the gamma-aminobutyric acid receptor complex in brain?” Brain Res, vol. 404, no. 1–2, Feb. 1987, pp. 355–60. Pubmed, doi:10.1016/0006-8993(87)91394-1. Full Text
Suzdak, P. D., et al. “A selective imidazobenzodiazepine antagonist of ethanol in the rat.” Science, vol. 234, no. 4781, Dec. 1986, pp. 1243–47. Pubmed, doi:10.1126/science.3022383. Full Text
Schwartz, R. D., et al. “γ-Aminobutyric acid (GABA)- and barbiturate-mediated 36Cl-uptake in rat brain synaptoneurosomes: Evidence for rapid desensitization of the GABA receptor-coupled chloride ion channel.” Molecular Pharmacology, vol. 30, no. 5, Dec. 1986, pp. 419–26.
Schwartz, R. D., et al. “gamma-Aminobutyric acid (GABA)- and barbiturate-mediated 36Cl- uptake in rat brain synaptoneurosomes: evidence for rapid desensitization of the GABA receptor-coupled chloride ion channel.” Mol Pharmacol, vol. 30, no. 5, Nov. 1986, pp. 419–26.
Paul, S. M., et al. “GABA receptor-mediated chloride transport in a "cell-free" membrane preparation from brain.” Science, vol. 233, no. 4760, July 1986, pp. 228–29. Pubmed, doi:10.1126/science.3014649. Full Text
Schwartz, R. D. “Autoradiographic distribution of high affinity muscarinic and nicotinic cholinergic receptors labeled with [3H]acetylcholine in rat brain.” Life Sci, vol. 38, no. 23, June 1986, pp. 2111–19. Pubmed, doi:10.1016/0024-3205(86)90210-9. Full Text