Rochelle D. Schwartz-Bloom
Professor Emeritus of Pharmacology & Cancer Biology
Dr. Schwartz-Bloom is a co-principal investigator for the National Science Foundation Phase II Noyce Fellowship program.
The Schwartz-Bloom laboratory has completed 18 years of research investigating novel pharmacologic approaches to prevent neuronal death caused by cerebral ischemia associated with cardiac arrest and stroke. The group studied how GABA neurotransmission dysfunction contributes to the death of hippocampal neurons after ischemia in vivo or in vitro. Dr. Schwartz-Bloom’s research program continued in the area of science education, which she started in 1996. Her science education research has included the development of novel science education curricular materials in the area of pharmacology to the K-12 and college community. One of the major programs that she developed is the Pharmacology Education Partnership (http://sites.duke.edu/thepepproject), a series of pharmacology- and drug abuse-related science education modules for high school biology and chemistry students. Testing of over 15,000 high school students has revealed that student performance in biology and chemistry improves when they use the pharmacology curriculum developed by her team. All of Dr. Schwartz-Bloom's science education research activities are found on her website for Raising Interest in Science Education, or RISE at http://sites.duke.edu/rise.
With funds provided by the Duke Provost in 2007, Dr. Schwartz-Bloom also established the Duke Center for Science Education, an umbrella for all Duke-related activities in science education. The Center helps to coordinate Duke faculty and student interests in curriculum development, research, and outreach activities in science education for the K-16 grades.
- Ph.D., Georgetown University 1983
Galeffi, F., et al. “Diazepam prevents changes in intracellular Cl- and Ca2+ and restores neuronal activity after ischemia in vitro.” Journal of Neurochemistry, vol. 81, BLACKWELL PUBLISHING LTD, June 2002, pp. 110–110.
Sah, Renu, et al. “Modulation of the GABA(A)-gated chloride channel by reactive oxygen species.” J Neurochem, vol. 80, no. 3, Feb. 2002, pp. 383–91. Pubmed, doi:10.1046/j.0022-3042.2001.00706.x. Full Text
Schwartz-Bloom, R. D., et al. “Measurement of chloride movement in neuronal preparations.” Curr Protoc Neurosci, vol. Chapter 7, May 2001, p. Unit7.10. Pubmed, doi:10.1002/0471142301.ns0710s04. Full Text
Schwartz-Bloom, R. D., and R. Sah. “gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia.” J Neurochem, vol. 77, no. 2, Apr. 2001, pp. 353–71. Pubmed, doi:10.1046/j.1471-4159.2001.00274.x. Full Text
Galeffi, F., et al. “Diazepam promotes ATP recovery and prevents cytochrome c release in hippocampal slices after in vitro ischemia.” J Neurochem, vol. 75, no. 3, Sept. 2000, pp. 1242–49. Pubmed, doi:10.1046/j.1471-4159.2000.0751242.x. Full Text
Galeffi, F., and R. D. Schwartz-Bloom. “Diazepam promotes ATP recovery following oxygen-glucose deprivation in the hippocampal slice.” Faseb Journal, vol. 14, no. 8, FEDERATION AMER SOC EXP BIOL, May 2000, pp. A1500–A1500.
Schwartz-Bloom, R. D., and M. J. Halpin. “Integrating high school biology & chemistry using pharmacology topics relevant to high schoolers: A model curriculum.” Faseb Journal, vol. 14, no. 8, FEDERATION AMER SOC EXP BIOL, May 2000, pp. A1495–A1495.
Schwartz-Bloom, R. D., et al. “Benzodiazepines protect hippocampal neurons from degeneration after transient cerebral ischemia: an ultrastructural study.” Neuroscience, vol. 98, no. 3, 2000, pp. 471–84. Pubmed, doi:10.1016/s0306-4522(00)00144-5. Full Text
Sah, R., and R. D. Schwartz-Bloom. “Optical imaging reveals elevated intracellular chloride in hippocampal pyramidal neurons after oxidative stress.” J Neurosci, vol. 19, no. 21, Nov. 1999, pp. 9209–17.