Rochelle D. Schwartz-Bloom
Professor Emeritus of Pharmacology & Cancer Biology
Dr. Schwartz-Bloom is a co-principal investigator for the National Science Foundation Phase II Noyce Fellowship program.
The Schwartz-Bloom laboratory has completed 18 years of research investigating novel pharmacologic approaches to prevent neuronal death caused by cerebral ischemia associated with cardiac arrest and stroke. The group studied how GABA neurotransmission dysfunction contributes to the death of hippocampal neurons after ischemia in vivo or in vitro. Dr. Schwartz-Bloom’s research program continued in the area of science education, which she started in 1996. Her science education research has included the development of novel science education curricular materials in the area of pharmacology to the K-12 and college community. One of the major programs that she developed is the Pharmacology Education Partnership (http://sites.duke.edu/thepepproject), a series of pharmacology- and drug abuse-related science education modules for high school biology and chemistry students. Testing of over 15,000 high school students has revealed that student performance in biology and chemistry improves when they use the pharmacology curriculum developed by her team. All of Dr. Schwartz-Bloom's science education research activities are found on her website for Raising Interest in Science Education, or RISE at http://sites.duke.edu/rise.
With funds provided by the Duke Provost in 2007, Dr. Schwartz-Bloom also established the Duke Center for Science Education, an umbrella for all Duke-related activities in science education. The Center helps to coordinate Duke faculty and student interests in curriculum development, research, and outreach activities in science education for the K-16 grades.
- Ph.D., Georgetown University 1983
Gabriel, E. M., et al. “Ischemic injury and extracellular amino acid accumulation in hippocampal area CA1 are not dependent upon an intact septo-hippocampal pathway.” Brain Res, vol. 785, no. 2, Mar. 1998, pp. 279–86. Pubmed, doi:10.1016/s0006-8993(97)01415-7. Full Text
Schwartz-Bloom, R. D. “Erratum: Long-term neuroprotection by benzodiazepine full versus partial agonists after transient cerebral ischemia in the gerbil (Journal of Cerebral Blood Flow and Metabolism (May 1998) 18 (548-558)).” Journal of Cerebral Blood Flow and Metabolism, vol. 18, no. 7, Jan. 1998, p. 817.
Inglefield, J. R., and R. D. Schwartz-Bloom. “Confocal imaging of intracellular chloride in living brain slices: measurement of GABAA receptor activity.” J Neurosci Methods, vol. 75, no. 2, Aug. 1997, pp. 127–35. Pubmed, doi:10.1016/s0165-0270(97)00054-x. Full Text
Inglefield, J. R., et al. “Effect of transient cerebral ischemia on gamma-aminobutyric acidA receptor alpha 1-subunit-immunoreactive interneurons in the gerbil CA1 hippocampus.” Hippocampus, vol. 7, no. 5, 1997, pp. 511–23. Pubmed, doi:10.1002/(SICI)1098-1063(1997)7:5<511::AID-HIPO7>3.0.CO;2-J. Full Text
Levin, E. D., et al. “Is binding to nicotinic acetylcholine and dopamine receptors related to working memory in rats?” Brain Res Bull, vol. 43, no. 3, 1997, pp. 295–304. Pubmed, doi:10.1016/s0361-9230(97)00009-9. Full Text
Fubara, B. M., et al. “Distribution of GABAA, GABAB, and glycine receptors in the central auditory system of the big brown bat, Eptesicus fuscus.” J Comp Neurol, vol. 369, no. 1, May 1996, pp. 83–92. Pubmed, doi:10.1002/(SICI)1096-9861(19960520)369:1<83::AID-CNE6>3.0.CO;2-G. Full Text
Schwartz-Bloom, R. D., et al. “Inhibition of GABA-gated chloride channels in brain by the arachidonic acid metabolite, thromboxane A2.” Neuropharmacology, vol. 35, no. 9–10, 1996, pp. 1347–53. Pubmed, doi:10.1016/s0028-3908(96)00059-7. Full Text
Alicke, B., and R. D. Schwartz-Bloom. “Rapid down-regulation of GABAA receptors in the gerbil hippocampus following transient cerebral ischemia.” J Neurochem, vol. 65, no. 6, Dec. 1995, pp. 2808–11. Pubmed, doi:10.1046/j.1471-4159.1995.65062808.x. Full Text
Schwartz, R. D., and X. Yu. “Optical imaging of intracellular chloride in living brain slices.” J Neurosci Methods, vol. 62, no. 1–2, Nov. 1995, pp. 185–92. Pubmed, doi:10.1016/0165-0270(95)00075-5. Full Text
Schwartz, R. D., et al. “Diazepam, given postischemia, protects selectively vulnerable neurons in the rat hippocampus and striatum.” J Neurosci, vol. 15, no. 1 Pt 2, Jan. 1995, pp. 529–39.