Rochelle D. Schwartz-Bloom
Professor in Pharmacology & Cancer Biology
Dr. Schwartz-Bloom is a co-principal investigator for the National Science Foundation Phase II Noyce Fellowship program.
The Schwartz-Bloom laboratory has completed 18 years of research investigating novel pharmacologic approaches to prevent neuronal death caused by cerebral ischemia associated with cardiac arrest and stroke. The group studied how GABA neurotransmission dysfunction contributes to the death of hippocampal neurons after ischemia in vivo or in vitro. Dr. Schwartz-Bloom’s research program continues now exclusively in science education, which she started in 1996. With funds provided by the Duke Provost in 2007, Dr. Schwartz-Bloom established Duke Center for Science Education, an umbrella for all Duke-related activities in science education. She coordinates Duke faculty and student interests in curriculum development, research, and outreach activities in science education for the K-16 grades. Dr. Schwartz-Bloom also directs RISE (Raising Interest in Science Education, http://sites.duke.edu/rise), an office within the Department of Pharmacology and Cancer Biology, where she develops and provides novel science education curricular materials in the area of pharmacology to the K-12 and college community. One of the major programs that she developed is the Pharmacology Education Partnership (http://sites.duke.edu/thepepproject), a series of pharmacology- and drug abuse-related science education modules for high school biology and chemistry students. Testing of over 15,000 high school students has revealed that student performance in biology and chemistry improves when they use the pharmacology curriculum developed by her team. Dr. Schwartz-Bloom provides several opportunities for Duke Pharmacology graduate students and post-doctoral fellows to obtain experience in teaching.
- Ph.D., Georgetown University 1983
Schwartz, RD, and Mindlin, MC. "Inhibition of the GABA receptor-gated chloride ion channel in brain by noncompetitive inhibitors of the nicotinic receptor-gated cation channel." J Pharmacol Exp Ther 244.3 (March 1988): 963-970.
Schwartz, RD, Skolnick, P, and Paul, SM. "Regulation of gamma-aminobutyric acid/barbiturate receptor-gated chloride ion flux in brain vesicles by phospholipase A2: possible role of oxygen radicals." J Neurochem 50.2 (February 1988): 565-571.
Luu, MD, Morrow, AL, Paul, SM, and Schwartz, RD. "Characterization of GABAA receptor-mediated 36chloride uptake in rat brain synaptoneurosomes." Life Sci 41.10 (September 7, 1987): 1277-1287.
Schwartz, RD, Wess, MJ, Labarca, R, Skolnick, P, and Paul, SM. "Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain." Brain Res 411.1 (May 12, 1987): 151-155.
Caspers, ML, Schwartz, RD, Labarca, R, and Paul, SM. "Autoradiographic visualization and characterization of [3H]ouabain binding to the Na+,K+-ATPase of rat brain and pineal." Brain Res 409.2 (April 21, 1987): 335-342.
Majewska, MD, and Schwartz, RD. "Pregnenolone-sulfate: an endogenous antagonist of the gamma-aminobutyric acid receptor complex in brain?." Brain Res 404.1-2 (February 24, 1987): 355-360.
Suzdak, PD, Glowa, JR, Crawley, JN, Schwartz, RD, Skolnick, P, and Paul, SM. "A selective imidazobenzodiazepine antagonist of ethanol in the rat." Science 234.4781 (December 5, 1986): 1243-1247.
Schwartz, RD, Suzdak, PD, and Paul, SM. "gamma-Aminobutyric acid (GABA)- and barbiturate-mediated 36Cl- uptake in rat brain synaptoneurosomes: evidence for rapid desensitization of the GABA receptor-coupled chloride ion channel." Mol Pharmacol 30.5 (November 1986): 419-426.
Paul, SM, Schwartz, RD, Creveling, CR, Hollingsworth, EB, Daly, JW, and Skolnick, P. "GABA receptor-mediated chloride transport in a "cell-free" membrane preparation from brain." Science 233.4760 (July 11, 1986): 228-229.