Rochelle D. Schwartz-Bloom
Professor Emeritus of Pharmacology & Cancer Biology
Dr. Schwartz-Bloom is a co-principal investigator for the National Science Foundation Phase II Noyce Fellowship program.
The Schwartz-Bloom laboratory has completed 18 years of research investigating novel pharmacologic approaches to prevent neuronal death caused by cerebral ischemia associated with cardiac arrest and stroke. The group studied how GABA neurotransmission dysfunction contributes to the death of hippocampal neurons after ischemia in vivo or in vitro. Dr. Schwartz-Bloom’s research program continued in the area of science education, which she started in 1996. Her science education research has included the development of novel science education curricular materials in the area of pharmacology to the K-12 and college community. One of the major programs that she developed is the Pharmacology Education Partnership (http://sites.duke.edu/thepepproject), a series of pharmacology- and drug abuse-related science education modules for high school biology and chemistry students. Testing of over 15,000 high school students has revealed that student performance in biology and chemistry improves when they use the pharmacology curriculum developed by her team. All of Dr. Schwartz-Bloom's science education research activities are found on her website for Raising Interest in Science Education, or RISE at http://sites.duke.edu/rise.
With funds provided by the Duke Provost in 2007, Dr. Schwartz-Bloom also established the Duke Center for Science Education, an umbrella for all Duke-related activities in science education. The Center helps to coordinate Duke faculty and student interests in curriculum development, research, and outreach activities in science education for the K-16 grades.
- Ph.D., Georgetown University 1983
Schwartz, R. D., et al. “Barbiturate and picrotoxin-sensitive chloride efflux in rat cerebral cortical synaptoneurosomes.” Febs Lett, vol. 175, no. 1, Sept. 1984, pp. 193–96. Pubmed, doi:10.1016/0014-5793(84)80597-9. Full Text
Rainbow, T. C., et al. “Quantitative autoradiography of nicotinic [3H]acetylcholine binding sites in rat brain.” Neurosci Lett, vol. 50, no. 1–3, Sept. 1984, pp. 193–96. Pubmed, doi:10.1016/0304-3940(84)90485-3. Full Text
Schwartz, R. D., et al. “Presynaptic nicotinic cholinergic receptors labeled by [3H]acetylcholine on catecholamine and serotonin axons in brain.” J Neurochem, vol. 42, no. 5, May 1984, pp. 1495–98. Pubmed, doi:10.1111/j.1471-4159.1984.tb02818.x. Full Text
Schwartz, R. D., et al. “Muscarinic cholinergic receptors labeled by [3H]acetylcholine in rat brain.” Federation Proceedings, vol. 43, no. 3, Jan. 1984.
Schwartz, R. D., and K. J. Kellar. “[3H]acetylcholine binding sites in brain. Effect of disulfide bond modification.” Mol Pharmacol, vol. 24, no. 3, Nov. 1983, pp. 387–91.
Schwartz, R. D., and K. J. Kellar. “Nicotinic cholinergic receptor binding sites in the brain: regulation in vivo.” Science, vol. 220, no. 4593, Apr. 1983, pp. 214–16. Pubmed, doi:10.1126/science.6828889. Full Text
Schwartz, R. D., and K. J. Kellar. “[3H]Acetylcholine binding sites in brain. Effect of disulfide bond modification.” Molecular Pharmacology, vol. 24, no. 3, 1983, pp. 387–91.
Schwartz, R. D., et al. “Nicotinic cholinergic receptors labeled by [3H]acetylcholine in rat brain.” Mol Pharmacol, vol. 22, no. 1, July 1982, pp. 56–62.
Schwartz, R. D., et al. “Effects of chronic phencyclidine on fixed-ratio responding: no relation to neurotransmitter receptor binding in rat cerebral cortex.” Pharmacol Biochem Behav, vol. 16, no. 4, Apr. 1982, pp. 647–52. Pubmed, doi:10.1016/0091-3057(82)90431-2. Full Text
Autrup, H., et al. “Metabolism of 1,2-dimethylhydrazine by cultured human colon.” Carcinogenesis, vol. 1, no. 5, May 1980, pp. 375–80. Pubmed, doi:10.1093/carcin/1.5.375. Full Text