Rochelle D. Schwartz-Bloom

Rochelle D. Schwartz-Bloom

Professor Emeritus of Pharmacology & Cancer Biology

External address: 
B238 LSRC Building, Durham, NC 27710
Internal office address: 
Duke Box 3813, Durham, NC 27710
Phone: 
(919) 684-5181

Dr. Schwartz-Bloom is a co-principal investigator for the National Science Foundation Phase II Noyce Fellowship program.

Overview

The Schwartz-Bloom laboratory has completed 18 years of research investigating novel pharmacologic approaches to prevent neuronal death caused by cerebral ischemia associated with cardiac arrest and stroke. The group studied how GABA neurotransmission dysfunction contributes to the death of hippocampal neurons after ischemia in vivo or in vitro. Dr. Schwartz-Bloom’s research program continued in the area of science education, which she started in 1996.  Her science education research has included the development of novel science education curricular materials in the area of pharmacology to the K-12 and college community. One of the major programs that she developed is the Pharmacology Education Partnership (http://sites.duke.edu/thepepproject), a series of pharmacology- and drug abuse-related science education modules for high school biology and chemistry students. Testing of over 15,000 high school students has revealed that student performance in biology and chemistry improves when they use the pharmacology curriculum developed by her team.  All of Dr. Schwartz-Bloom's science education research activities are found on her website for Raising Interest in Science Education, or RISE  at http://sites.duke.edu/rise.  

With funds provided by the Duke Provost in 2007, Dr. Schwartz-Bloom also established the Duke Center for Science Education, an umbrella for all Duke-related activities in science education. The Center helps to coordinate Duke faculty and student interests in curriculum development, research, and outreach activities in science education for the K-16 grades.

Education

  • Ph.D., Georgetown University 1983

Schwartz, R. D., et al. “Bidirectional modulation of GABA-gated chloride channels by divalent cations: inhibition by Ca2+ and enhancement by Mg2+..” J Neurochem, vol. 62, no. 3, Mar. 1994, pp. 916–22. Pubmed, doi:10.1046/j.1471-4159.1994.62030916.x. Full Text

Schwartz, R. D., et al. “Erratum: Postischemic diazepam is neuroprotective in the gerbil hippocampus (Brain Research 647 (1994) (153-160)) (BRES 26140).” Brain Research, vol. 655, no. 1–2, Jan. 1994, pp. 279–80. Scopus, doi:10.1016/0006-8993(94)91629-2. Full Text

Li, H., et al. “Rapid decline of GABAA receptor subunit mRNA expression in hippocampus following transient cerebral ischemia in the gerbil..” Hippocampus, vol. 3, no. 4, Oct. 1993, pp. 527–37. Pubmed, doi:10.1002/hipo.450030412. Full Text

Schwartz, R. D., and X. Yu. “Inhibition of GABA-gated chloride channel function by arachidonic acid..” Brain Res, vol. 585, no. 1–2, July 1992, pp. 405–10. Pubmed, doi:10.1016/0006-8993(92)91246-b. Full Text

Edgar, P. P., and R. D. Schwartz. “Functionally relevant gamma-aminobutyric acidA receptors: equivalence between receptor affinity (Kd) and potency (EC50)?.” Mol Pharmacol, vol. 41, no. 6, June 1992, pp. 1124–29.

Mileson, B. E., et al. “Alterations in the gamma-aminobutyric acid-gated chloride channel following transient forebrain ischemia in the gerbil..” J Neurochem, vol. 58, no. 2, Feb. 1992, pp. 600–07. Pubmed, doi:10.1111/j.1471-4159.1992.tb09761.x. Full Text

Schwartz, R. D., et al. “Cellular regulation of the benzodiazepine/GABA receptor: arachidonic acid, calcium, and cerebral ischemia..” Neuropsychopharmacology, vol. 6, no. 2, Feb. 1992, pp. 119–25.

Mileson, B. E., and R. D. Schwartz. “The use of locomotor activity as a behavioral screen for neuronal damage following transient forebrain ischemia in gerbils..” Neurosci Lett, vol. 128, no. 1, July 1991, pp. 71–76. Pubmed, doi:10.1016/0304-3940(91)90762-i. Full Text

McCown, T. J., et al. “Unilateral kindling of the inferior collicular cortex does not transfer to the contralateral seizure sensitive site or alter [3H]flunitrazepam and [35S]TBPS binding..” Epilepsy Res, vol. 9, no. 2, July 1991, pp. 132–38. Pubmed, doi:10.1016/0920-1211(91)90024-a. Full Text

Schwartz, R. D., et al. “cAMP analogs inhibit gamma-aminobutyric acid-gated chloride flux and activate protein kinase A in brain synaptoneurosomes..” Mol Pharmacol, vol. 39, no. 3, Mar. 1991, pp. 370–75.

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