Rochelle D. Schwartz-Bloom
Professor Emeritus of Pharmacology & Cancer Biology
Dr. Schwartz-Bloom is a co-principal investigator for the National Science Foundation Phase II Noyce Fellowship program.
The Schwartz-Bloom laboratory has completed 18 years of research investigating novel pharmacologic approaches to prevent neuronal death caused by cerebral ischemia associated with cardiac arrest and stroke. The group studied how GABA neurotransmission dysfunction contributes to the death of hippocampal neurons after ischemia in vivo or in vitro. Dr. Schwartz-Bloom’s research program continued in the area of science education, which she started in 1996. Her science education research has included the development of novel science education curricular materials in the area of pharmacology to the K-12 and college community. One of the major programs that she developed is the Pharmacology Education Partnership (http://sites.duke.edu/thepepproject), a series of pharmacology- and drug abuse-related science education modules for high school biology and chemistry students. Testing of over 15,000 high school students has revealed that student performance in biology and chemistry improves when they use the pharmacology curriculum developed by her team. All of Dr. Schwartz-Bloom's science education research activities are found on her website for Raising Interest in Science Education, or RISE at http://sites.duke.edu/rise.
With funds provided by the Duke Provost in 2007, Dr. Schwartz-Bloom also established the Duke Center for Science Education, an umbrella for all Duke-related activities in science education. The Center helps to coordinate Duke faculty and student interests in curriculum development, research, and outreach activities in science education for the K-16 grades.
- Ph.D., Georgetown University 1983
McCown, T. J., et al. “Unilateral kindling of the inferior collicular cortex does not transfer to the contralateral seizure sensitive site or alter [3H]flunitrazepam and [35S]TBPS binding.” Epilepsy Res, vol. 9, no. 2, July 1991, pp. 132–38. Pubmed, doi:10.1016/0920-1211(91)90024-a. Full Text
Schwartz, R. D., et al. “cAMP analogs inhibit gamma-aminobutyric acid-gated chloride flux and activate protein kinase A in brain synaptoneurosomes.” Mol Pharmacol, vol. 39, no. 3, Mar. 1991, pp. 370–75.
Edgar, P. P., and R. D. Schwartz. “Localization and characterization of 35S-t-butylbicyclophosphorothionate binding in rat brain: an autoradiographic study.” J Neurosci, vol. 10, no. 2, Feb. 1990, pp. 603–12.
Navarro, H. A., et al. “Prenatal exposure to nicotine impairs nervous system development at a dose which does not affect viability or growth.” Brain Res Bull, vol. 23, no. 3, Sept. 1989, pp. 187–92. Pubmed, doi:10.1016/0361-9230(89)90146-9. Full Text
Tilson, H. A., et al. “Colchicine administered into the area of the nucleus basalis decreases cortical nicotinic cholinergic receptors labelled by [3H]-acetylcholine.” Neuropharmacology, vol. 28, no. 8, Aug. 1989, pp. 855–61. Pubmed, doi:10.1016/0028-3908(89)90178-0. Full Text
Heuschneider, G., and R. D. Schwartz. “cAMP and forskolin decrease gamma-aminobutyric acid-gated chloride flux in rat brain synaptoneurosomes.” Proc Natl Acad Sci U S A, vol. 86, no. 8, Apr. 1989, pp. 2938–42. Pubmed, doi:10.1073/pnas.86.8.2938. Full Text
Schwartz, R. D., et al. “Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding.” Brain Res, vol. 481, no. 1, Feb. 1989, pp. 169–74. Pubmed, doi:10.1016/0006-8993(89)90499-x. Full Text
Schwartz, R. D. “The GABAA receptor-gated ion channel: biochemical and pharmacological studies of structure and function.” Biochem Pharmacol, vol. 37, no. 18, Sept. 1988, pp. 3369–75. Pubmed, doi:10.1016/0006-2952(88)90684-3. Full Text
Suzdak, P. D., et al. “Alcohols stimulate gamma-aminobutyric acid receptor-mediated chloride uptake in brain vesicles: correlation with intoxication potency.” Brain Res, vol. 444, no. 2, Mar. 1988, pp. 340–45. Pubmed, doi:10.1016/0006-8993(88)90943-2. Full Text
Schwartz, R. D., and M. C. Mindlin. “Inhibition of the GABA receptor-gated chloride ion channel in brain by noncompetitive inhibitors of the nicotinic receptor-gated cation channel.” J Pharmacol Exp Ther, vol. 244, no. 3, Mar. 1988, pp. 963–70.