Rochelle D. Schwartz-Bloom
Professor Emeritus of Pharmacology & Cancer Biology
Dr. Schwartz-Bloom is a co-principal investigator for the National Science Foundation Phase II Noyce Fellowship program.
The Schwartz-Bloom laboratory has completed 18 years of research investigating novel pharmacologic approaches to prevent neuronal death caused by cerebral ischemia associated with cardiac arrest and stroke. The group studied how GABA neurotransmission dysfunction contributes to the death of hippocampal neurons after ischemia in vivo or in vitro. Dr. Schwartz-Bloom’s research program continued in the area of science education, which she started in 1996. Her science education research has included the development of novel science education curricular materials in the area of pharmacology to the K-12 and college community. One of the major programs that she developed is the Pharmacology Education Partnership (http://sites.duke.edu/thepepproject), a series of pharmacology- and drug abuse-related science education modules for high school biology and chemistry students. Testing of over 15,000 high school students has revealed that student performance in biology and chemistry improves when they use the pharmacology curriculum developed by her team. All of Dr. Schwartz-Bloom's science education research activities are found on her website for Raising Interest in Science Education, or RISE at http://sites.duke.edu/rise.
With funds provided by the Duke Provost in 2007, Dr. Schwartz-Bloom also established the Duke Center for Science Education, an umbrella for all Duke-related activities in science education. The Center helps to coordinate Duke faculty and student interests in curriculum development, research, and outreach activities in science education for the K-16 grades.
- Ph.D., Georgetown University 1983
Schwartz, R. D. “Autoradiographic distribution of high affinity muscarinic and nicotinic cholinergic receptors labeled with [3H]acetylcholine in rat brain.” Life Sci, vol. 38, no. 23, June 1986, pp. 2111–19. Pubmed, doi:10.1016/0024-3205(86)90210-9. Full Text
Suzdak, P. D., et al. “Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptoneurosomes.” Proc Natl Acad Sci U S A, vol. 83, no. 11, June 1986, pp. 4071–75. Pubmed, doi:10.1073/pnas.83.11.4071. Full Text
Majewska, M. D., et al. “Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor.” Science, vol. 232, no. 4753, May 1986, pp. 1004–07. Pubmed, doi:10.1126/science.2422758. Full Text
Schwartz, R. D., et al. “Demonstration of GABA/barbiturate-receptor-mediated chloride transport in rat brain synaptoneurosomes: a functional assay of GABA receptor-effector coupling.” Adv Biochem Psychopharmacol, vol. 41, 1986, pp. 33–49.
Schwartz, R. D., et al. “Factors modulating the sensitivity of the GABA receptor-gated chloride ion channel.” Clin Neuropharmacol, vol. 9 Suppl 4, 1986, pp. 389–91.
Schwartz, R. D., et al. “Characterization of barbiturate-stimulated chloride efflux from rat brain synaptoneurosomes.” J Neurosci, vol. 5, no. 11, Nov. 1985, pp. 2963–70.
Schwartz, R. D., and K. J. Kellar. “In vivo regulation of [3H]acetylcholine recognition sites in brain by nicotinic cholinergic drugs.” J Neurochem, vol. 45, no. 2, Aug. 1985, pp. 427–33. Pubmed, doi:10.1111/j.1471-4159.1985.tb04005.x. Full Text
Schwartz, R. D., et al. “Radiation inactivation studies of the benzodiazepine/gamma-aminobutyric acid/chloride ionophore receptor complex.” J Neurochem, vol. 45, no. 1, July 1985, pp. 108–15. Pubmed, doi:10.1111/j.1471-4159.1985.tb05481.x. Full Text
Kellar, K. J., et al. “High-affinity binding of [3H]acetylcholine to muscarinic cholinergic receptors.” J Neurosci, vol. 5, no. 6, June 1985, pp. 1577–82.
Clarke, P. B., et al. “Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin.” J Neurosci, vol. 5, no. 5, May 1985, pp. 1307–15.